PTEN and neoplasm: It functions in converting phosphatidylinositol-3,4,5-triphosphate (PIP3) into a diphosphate product (PIP2), inducing the antagonism of the phosphatidylinositol-3 kinase (PI3K) pathway and subsequently restraining tumor progress such as cell growth, apoptosis, adhesion, migration and invasion.12, 13 Currently, PTEN is widely researched and has been demonstrated to suppress the development of various carcinomas.