SPRY2 and breast cancer: Aberrant expression of miR-21 contributed to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways.14 Moreover, PTEN, together with SPRY2 and PP2A, drived tumorigenesis and metastasis in prostate cancer.15 For breast cancer, decreased PTEN expression has been reported to correlate with aggressive breast cancer phenotype and poor prognosis of the disease.16, 17 However, whether miR-106b and miR-93 could collectively regulate PTEN expression in breast cancer remained unclear.