AKT1 and breast cancer: As proved, p-Akt 308 and p-Akt 473, the phosphorylation of Akt, promoted tumor invasion and chemoresistance of breast carcinoma.38, 39 In this article, when siAkt was utilized to inhibit the expression of p-Akt 308 and p-Akt 473 in breast cancer, the capability of cell migration, invasion and proliferation was significantly attenuated, indicating that the phosphorylation of Akt did have a role in the progression of breast cancer.