Ion channels are in a strategic position to sense and transmit extracellular signals into the intracellular machinery,29, 30 which serve as a basis for each major step of the metastatic cascade including EMT.31, 32 So far, the role of ASIC1 and ASIC3 in cell migration and proliferation has been mainly shown in astrocytes, glioblastoma and breast cancer, whereas its role in other cancers has not been well elucidated.22, 23, 33 Much of our present work stems from ASIC1 and ASIC3 are the most sensitive to acidity in ASICs. Here, ASIC3 is linked to breast cancer.