It has been demonstrated that the Ca2+ permeability of ASICs provides a voltage-independent pathway for Ca2+ entry into cells.16 Moreover, the intracellular Ca2+ concentration ([Ca2+]i) is ubiquitous second messenger and acts as a crucial regulator of cell migration, which has a profound role in tumor metastasis.24 We therefore wondered whether ASIC1 and ASIC3 may contribute to the acidity-induced EMT through regulating [Ca2+]i. Here, ASIC1 is linked to neoplasm.