For example, the moonwalker mouse model carries a mutation leading to constitutive activation of TRPC3 channels and a dominantly inherited cerebellar ataxia (Becker et al., 2009; Becker, 2014); perhaps relatedly, mutated forms of PKCγ found in SCA14 fail to phosphorylate TRP channels resulting in sustained Ca2+ entry into PNs (Adachi et al., 2008). Here, TRPC3 is linked to aceruloplasminemia.