Complex transcriptional changes involving genes related to the mGluR1 signal cascade have been reported in several SCA mouse models (Lin et al., 2000; Serra et al., 2004; Hansen et al., 2013; Notartomaso et al., 2013; Bettencourt et al., 2014; Dansithong et al., 2015); however, few studies have examined the physiological consequences of such changes. The gene discussed is GRM1; the disease is autosomal dominant cerebellar ataxia.