Given the paucity of genetically accurate models for AML1-ETO AML based on co-occurring genetic lesions, the models presented in this study may be critical for understanding AML1-ETO disease pathogenesis further in addition to providing conditional alleles to define the role of ASXL2 outside of the haematopoietic system. The gene discussed is RUNX1; the disease is acute myeloid leukemia.