Analysis of peripheral blood of Asxl2-deficient mice revealed that in contrast to the modest effects of Asxl1 deletion on white blood cell (WBC) and platelet counts, Asxl2 deletion resulted in rapid leukopenia and thrombocytopenia in recipient mice which was associated with hastened death of recipient mice (Fig. 1e–g). Here, ASXL1 is linked to Decreased total leukocyte count.