RUNX1T1 and acute myeloid leukemia: Consistent with this, motif enrichment analysis of ASXL2-binding sites in these same SKNO−1 cells revealed a strong overlap of ASXL2 binding with ETS as well as AP−1 transcription factors, all established as interacting physically with the AML1-ETO transcriptional complex in human t(8;21) (ref. 33) AML (Supplementary Fig. 5d; Supplementary Data 5 shows all significantly enriched motifs under ASXL2 ChIP-seq peaks, of which ETS and AP−1 motifs represent only a subset).