We therefore next examined the overlap between genes differentially expressed in Asxl2-deficient LSK cells and those which are known targets of AML1-ETO or RUNX1 based on previously published chromatin immunoprecipitation next-generation sequencing (ChIP-seq) studies in ASXL1/2-WT AML1-ETO-expressing human AML cells29, 30. The gene discussed is RUNX1; the disease is acute myeloid leukemia.