Mx1-cre Aml1-Eto Asxl2fl/WT mice expressing NRASG12D developed worsened anaemia and thrombocytopenia as well as greater circulating GFP/c-Kit double-positive cells and hastened death compared with counterpart Mx1-cre Aml1-Eto Asxl2 WT mice expressing NRASG12D. The gene discussed is RUNX1; the disease is anemia (phenotype).