This contrasts with the finding that the selective inhibition of human BET BD2 in liver cancer cells induced only minor effects on transcriptional regulation43 and that BD1 plays a more important role than BD2 in Brdt-mediated chromatin remodelling44, in recruiting Brd3 to acetylated sites on GATA1 (ref. 45), and in chromatin binding by Brd4 (ref. 46). This evidence concerns the gene DEFB1 and liver cancer.