In orthotropic xenografted nude mice, hCINAP depletion induced by doxycycline administration suppressed LDHA Y10 phosphorylation (Fig. 7c) and significantly impaired tumour growth in vivo, whereas re-expression of wild-type hCINAP, but not H79G mutant hCINAP, in hCINAP-depleted CRCSCs compensated for the knockdown effect on tumour growth. Here, LDHA is linked to neoplasm.