FLT3 and neoplasm: Furthermore, in nude mice xenografted with Ba/F3 cells expressing either FLT3-ITD, FLT3-D835Y, or FLT3-ITD-D835Y, gilteritinib showed antitumor efficacy at 10 mg/kg and 30 mg/kg, and induced tumor regression at 30 mg/kg, in all three models (Fig. 3).