Furthermore, previous studies indicated that an altered activity of the purinergic receptors mediates the proinflammatory processes in a transgenic AD model and in brains from AD patients [27–29] and in vivo inhibition of P2X7 receptors significantly reduces the amyloid plaques formation in brain hippocampal structures through activation of α-secretase activity [59]. Here, P2RX4 is linked to Alzheimer disease.