Targeting Bcl-2/IP3R complex with Bcl-2/IP3 receptor disrupter-2 (BIRD-2), a stabilized TAT-linked peptide containing the 20 amino acids that represent the Bcl-2 interaction motif of IP3Rs, triggers intracellular Ca2+ overload and apoptotic cell death in a variety of cancer cell models, including chronic lymphocytic leukemia (81), diffuse large B-cell lymphoma (89), multiple myeloma, follicular lymphoma (90), and small-cell lung carcinoma (91). Here, ITPR3 is linked to B-cell chronic lymphocytic leukemia.