EZH2 and cancer: Our earlier studies had shown that the activation of the FGF-2/KDM2B-EZH2/miR-101/EZH2 pathway in bladder and other cancers, promotes cell migration, cancer stem cell self-renewal, cell proliferation and angiogenesis.11,12 Cell migration is a function often associated with EMT, which is known to be induced by EZH2, one of the effectors of this pathway.28,29 We therefore suggest that the correlation between FGF-2 and EMT in bladder cancer (Figure 2) may be due to the induction of EMT via the FGF-2/KDM2B-EZH2/miR-101/EZH2 pathway, which is active in these tumors.