PDE4 is selective for cAMP (Boswell-Smith et al., 2006; Maurice et al., 2014) and in adult animal model of sepsis, inhibitors of PDE4 reduce systemic vascular resistance (Carcillo et al., 1996), improve cardiac contractility (Thomas et al., 2003) and improve renal function (Carcillo et al., 1996; Tanahashi et al., 1999; Holthoff et al., 2013). Here, PDE4A is linked to Sepsis.