AGT and neurodegenerative disease: As indicated above, Ang II, via its AT1 receptor, is a major activator of the NADPH-oxidase complex (Zalba et al., 2001; Hoogwerf, 2010), and NADPH-dependent oxidases mediate several key aspects of OS and inflammatory processes that are involved in major degenerative diseases in peripheral tissues (Griendling et al., 2000; Münzel and Keaney, 2001).