AGTR1 and Alzheimer disease: Indeed, AT1 receptor antagonists exerted positive effects in several processes mediated by microglial activation and neuroinflammation, such as experimental models of multiple sclerosis (Platten et al., 2009; Stegbauer et al., 2009), Alzheimer’s disease (AD; Kehoe and Wilcock, 2007; Mogi and Horiuchi, 2009; Torika et al., 2016) and brain ischemia (Iwanami et al., 2010).