Interestingly, neurons in areas vulnerable to Alzheimer’s disease (AD; e.g., basal forebrain cholinergic neurons) show partial GLUT-4 dependence, which may help explain their vulnerability in low energy conditions and AD (Morgello et al., 1995; Apelt et al., 1999; Duelli and Kuschinsky, 2001). The gene discussed is SLC2A4; the disease is Alzheimer disease.