BST1 and Anxiety: In our previous studies, CD157 KO mice displayed severe anxiety-like behaviors in the novel environment and in the presence of a novel non-social object, and a weak sociability against a social target in the OFT, and an abnormal sociability in a three-chamber paradigm (Lopatina et al., 2014; Mizuno et al., 2015; Higashida et al., 2017).