As our previous reports showed that REST enhanced the expression of transcription factor FOXO1, an anti-apoptotic protein, which also mediates oxidative stress resistance (Kajihara et al., 2006; Tothova et al., 2007) and is protected by REST in AD (Lu et al., 2014), we further explored the correlation of REST with oxidative stress in our in vitro prion disease model. Here, REST is linked to Alzheimer disease.