AKT1 and scrapie: In particular, p-Akt (Ser473) and p-mTOR (Ser2448), biochemical indicators of Akt and mTOR activation (Hay and Sonenberg, 2004), were decreased to an almost undetectable level in the brains of scrapie-infected hamsters, suggesting nearly complete inactivation of the Akt-mTOR pathway, whereas levels of total Akt protein had no significant change.