FUS and amyotrophic lateral sclerosis: Since defects in the shuttling of proteins and RNAs between the nucleus and the cytoplasm are emerging as a crucial issue in ALS pathogenesis28, we suggest that the proper regulation of nucleocytosolic shuttling of snRNAs and snRNPs may be also affected by wild-type FUS overexpression, similarly to what has been observed in presence of FUS mutant proteins.