TRAF6 and disease arising from reactivation of latent virus: This analysis revealed an intricate association of DNA methylation with a broad range of pathways potentially related with the DM or TB pathogenesis, including “latent infection of Homo sapiens with Mycobacterium tuberculosis”, “TRAF6 mediated induction of TAK1 complex”, “Complement cascade”, “Lipid digestion, mobilization, and transport”, and “Cellular senescence” (Fig. 7C).