Additionally, the potentially causal link between epidermal loss of DLX3 expression and human skin cancer25, and the finding of DLX3 downregulation in B cells with the MLL-AF4 translocation in acute lymphoblastic leukemia in children26 suggest normal postnatal expression of DLX3 in certain tissue and cell types is also required. This evidence concerns the gene DLX3 and acute lymphoblastic leukemia.