TGFB1 and cancer: TGFβ1 concentration difference profile (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${\rm{\Delta }}{C}_{TGF\beta 1}=C-{C}_{0}$$\end{document}ΔCTGFβ1=C−C0) around an empty hole (center) that is surrounded by eight cancer cell-containing hole is shown in Fig. 4B.