For example, positive cytoplasmic YB-1 staining was seen in 80.4% (including 27% cases with nuclear co-staining) of ERG-IHC negative but in 95.1% (34.2% nuclear co-staining) of ERG-IHC positive cancers (p ≤ 0.05 each). The gene discussed is YBX1; the disease is cancer.