ERG and cancer: Further analyses in ERG-negative and ERG-positive cancers revealed that the prognostic impact of both cytoplasmic and nuclear YB-1 staining was strictly limited to the subset of ERG-negative cancers (p < 0.0001 each for cytoplasmic and combined cytoplasmic/nuclear staining, Fig. 4c,d) but not seen in ERG-positive cancers (Fig. 4e,f).