TP53 and colorectal cancer: We used the p53-null HCT-116 cells and the mutant p53.R273H HT-29 cells (Supplementary Figure 1, IARC TP53 Database), to determine whether this translational regulation occurs in different colorectal cancer cell lines and whether it is dependent of p53 since several data support a role of p53 as a regulator of translational reprogramming [28].