While SKH-1 mice with persistent papillomas were able to completely clear their warts after vaccination with hCRT-mE6mE7mL2 DNA, their E6-specific CD8 T cell response was significantly lower after vaccination than the responses to hCRT-mE6mE7mL2 DNA seen in mice that cleared their papillomas or never developed papillomas prior to vaccination. The gene discussed is HCRT; the disease is papilloma.