PTH and skeletal dysplasia: Acrodysostosis is a very rare congenital multisystem condition characterized by (1) skeletal dysplasia with severe brachydactyly, midfacial hypoplasia, and short stature, (2) varying degrees of intellectual disability, and (3) possible resistance to multiple G protein-coupled receptor (GPCR) signalling hormones, including parathyroid hormone (PTH) and thyrotropin (TSH) (1,2).