Previous reports describe a molecular connection between nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) and the regulation of β1 integrin expression [44, 45], which is known to engage in prosurvival crosstalk with JNK signaling to promote mesenchymal differentiation together with radioresistance of GBM [46]. Here, MAPK8 is linked to glioblastoma.