JNK's aberrant phosphorylation and activity in human GBM emphasizes a critical involvement in prosurvival signaling that facilitates tumor progression through regulation of self-renewal and tumor-initiating properties of GBM stem-like cells and their resistance to the standard therapeutic Temozolomide (TMZ) by regulating MGMT expression [16–21]. The gene discussed is MGMT; the disease is glioblastoma.