In patients with malignant pleural mesothelioma, pancreatic cancer, non-small cell lung cancer and hepatocellular carcinoma elevated CRP levels were associated with significantly worse prognosis [19, 20, 22, 25] Multivariable analysis revealed CRP as an independent prognostic predictor in patients with malignant diseases of much poorer overall prognosis than TETs: malignant pleural mesothelioma (CRP ≥ 1 mg/dL; OS) [19]; non-small cell lung cancer (CRP > 1 mg/dL; CSS) [20]; adenocarcinoma of the pancreas (CRP > 4.5 mg/dL; CSS) [22]; hepatocellular carcinoma (CRP > 0.2 mg/dL; FFR). The gene discussed is CRP; the disease is familial pancreatic carcinoma.