The panel of four-biomarker conducted well for characterization of patients with lung cancer, offering 0.974 AUC and 90.3% sensitivity (95% CI, 87.0% to 93.0%) at 95% specificity, which was both significantly higher than MIC-1 alone and the other three biomarker combination tested (Figure 4A). The gene discussed is GDF15; the disease is lung cancer.