For example, alterations of several proteins (e.g., annexin A4, cyclophilin A, cathepsin D, galectin-1, 14-3-3ζ, α-enolase, peroxiredoxin I, TM2, and S100A8) were reported in PC compared with normal and pancreatitis tissues by a 2DE and MS approach [13]. The gene discussed is CTSD; the disease is pachyonychia congenita.