ALK and non-small cell lung carcinoma: Based on an optimal cut-off value (−1.493) that was chosen using Youden's Index, the sensitivity and specificity of miR-28-5p were 65.85% and 96.88% for distinguishing patients with ALK-positive NSCLC from those with ALK-negative NSCLC (area under curve [AUC] = 0.873, 95% CI, 0.795–0.952).