EBV-encoded LMP2A is a dedicated activator of mTOR in latent EBV infection (Cen and Longnecker, 2015, Moody et al., 2005) that is also expressed in the viral lytic phase (Yuan et al., 2006), suggesting it may trigger PDCD4 loss. The gene discussed is PDCD4; the disease is Epstein-Barr virus infection.