The TNFAIP3 gene can encode the protein A20, which involves in the pathogenesis of autoimmune diseases.[7] Several publications have appeared to identify the TNFAIP3 gene as a susceptibility locus for the human autoimmune pathology.[8,9,15,26–28] The TNFAIP3 gene is also regarded to closely associate with the autoimmune diseases. The gene discussed is TNFAIP3; the disease is autoimmune disease.