We hypothesized that the generic variants in the TNFAIP3 gene may have an association with the MG, and in the current report, we performed a research to explore the association of polymorphisms in the TNFAIP3 gene with MG, and furthermore examine the relationship between the generic variations of TNFAIP3 gene and clinical manifestations for this disease. This evidence concerns the gene TNFAIP3 and myasthenia gravis.