YAP1 and neoplasm: In fact, the YAP/TAZ-Notch connection here described may be also compatible with a scenario in which YAP/TAZ, known for being expressed in cancer stem cells36, may preserve their undifferentiated state by cis-inhibition of Notch, and, at the same time, induce proliferation of neighbouring tumour cells by trans-activation of Notch signalling.