Consistent with this idea and with the established role of YAP/TAZ and Notch signalling in skin carcinogenesis26, 33, 36, we also found that YAP/TAZ and Notch transcriptional signatures are anticorrelated in skin tumour samples (mouse skin chemical carcinogenesis or human skin squamous cell carcinoma cell lines versus their normal counterpart; Supplementary Fig. 4b,c). Here, YAP1 is linked to skin squamous cell carcinoma.