ACP5 and myeloid sarcoma: Unlike these studies, other researchers, using a fructose-rich diet (FRD), constructed the metabolic syndrome (MS) animal model and assessed the effects of FRD-induced MS on long bone histomorphometry and bone tissue regeneration [17], finding a 20% decrease in the osteocytic density of femoral trabecular bone and a 30% reduction in osteoclast-covered (TRAP-positive) bone surface in the primary spongiosa in the FRD group.