Other mechanisms of action by which EGFR inhibition decrease tumour growth include the inhibition of angiogenic activity by reducing the secretion of vascular endothelial growth factor (VEGF), decreasing cell invasion and metastasis by inhibiting the production of matrix metalloproteinase, and through the promotion of apoptosis in EGFR-addicted cancer cells (reviewed in [412]). The gene discussed is EGFR; the disease is cancer.