NAE1 and early-onset autosomal dominant Alzheimer disease: In the Alzheimer’s disease pathway, we found genes up-regulated (Apbb1, Atf6, Cacna1d, Calm3, Casp7, Itpr1, Lpl, and Ppp3ca) and down-regulated (Aph1b, Bid, Cycs, Fadd, Fas, and Nae1).