The first link between LSDs and Parkinson’s disease (PD) have been demonstrated a decade ago for Gaucher disease, and then extended to others, such as Niemann–Pick type I e II (NPC1, NPC2), GM1 and GM2 gangliosidosis, neuronal ceroid lipofuscinoses and Fabry disease [64]. This evidence concerns the gene NPC2 and Fabry disease.