IDS and early-onset autosomal dominant Alzheimer disease: Interestingly, among the data obtained in this RNA-seq study, α-synuclein (Snca) transcript, involved in the death of dopaminergic neurons and implicated in several neurodegenerative diseases as Alzheimer disease and Parkinson disease [51], is up-regulated in both Cx and M areas of the Ids-ko mice, supporting an hypothesis of similarity between LSDs and chronic neurodegenerative diseases, as previously proposed by others [52].