There can be several causes that lead to mitochondrial dysregulation: the lysosomal impairment that characterizes all LSDs, but also the oxidative stress, autophagy, calcium dyshomeostasis and the accumulation of proteins, such as those characterizing some neurodegenerative diseases (i.e., α-synuclein in Parkinson’s disease) [62]. This evidence concerns the gene SNCA and neurodegenerative disease.