Moreover, beneficial effects of facilitating the nuclear import of Nrf2 by other Nrf2 activators, such as hydrogen sulfide [100], hepatocyte growth factor [103], and tert-butylhydroquinone [105], were proved in many experimental DN models, indicating the importance of the regulation of cytoplasm-to-nuclear shuttling of Nrf2 in the treatment of DN. Here, NFE2L2 is linked to liver dysplastic nodule.