CD4 and B-cell chronic lymphocytic leukemia: Further support for a skewed T-cell compartment comes from CD4+ CLL-T cells having decreased gene expression of the JNK and p38 MAPK pathway activators (MINK, NFRKB, PIK3CB) (26) suggesting a defect in Th1 differentiation as the aforementioned genes are crucial in the production of IFN-γ (29–31).