CDC42 and B-cell chronic lymphocytic leukemia: Phenotypically, immune synapse malformation of CLL-T cells is displayed as a decrease in T-cell–APC conjugation and F-actin polymerization, with further decrement in T-cell receptor, WASp, Dynamin-2, Lck, Cdc42, and Filamin-A recruitment to the synapse site (40, 41).