TNF and Pancytopenia: On the other hand, HPVB19 infection reportedly induces VAHS, which increases circulating CD8+ cytotoxic T cells and IFN-γ and TNF-α secretion, triggering symptoms such as high fever, liver injury, enlarged liver and spleen, coagulation factor abnormalities, pancytopenia, and a build-up of histiocytes in various tissues resulting in the destruction of blood-producing cells [19–21].