At this point, it is reasonable to think that several antibodies can act as predictors in the diagnosis of this malignancy and, in fact, protein p53 antibodies IgA and IgG have been found in the serum and saliva of patients who overexpressed p53 in their tumor tissues, demonstrating that the detection of these antibodies could identify oral squamous cell carcinoma with p53 mutations, which occurs in 50% of cases (44,45). This evidence concerns the gene TP53 and neoplasm.