TARDBP and amyotrophic lateral sclerosis: TDP-43 was also identified as the pathological protein in frontotemporal lobar degeneration (FTLD)-related ubiquitinated inclusions, supporting the idea that ALS and FTD reside on the same spectrum of disease (Arai et al., 2006; Neumann et al., 2006; reviewed in Swinnen and Robberecht, 2014).