Loss of C9orf72 in neurons inhibited autophagy and caused accumulation of p62/sequestosome-1 (Sellier et al., 2016; Webster et al., 2016a) while C9ALS/FTD patient-derived iNeurons exhibited reduced basal autophagy levels compared to controls (Webster et al., 2016a). The gene discussed is C9orf72; the disease is frontotemporal dementia.