IL6 and colitis: O’Shea et al. 13 recently exposed Adamdec1−/− mice to dextran sodium sulfate or infected them orally with Citrobacter rodentium or Salmonella typhimurium, finding that the loss of Adamdec1 rendered mice more susceptible to the induction of bacterial and chemical-induced colitis, as evidenced by increased neutrophil infiltration, greater IL-6 and IL-1β secretion, more weight loss and increased mortality.