This may be related to the increased amount of systemic inflammation observed within the same obesity range, as higher concentrations of complement C3, C-reactive protein, IFN, TNF-α, and IL-6, as well as lower levels of adiponectin, have been observed in the metabolic unhealthy group as compared to the metabolic healthy group30, 31. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.