Moreover, obesity induces a shift in the population of adipose tissue-resident immune cells, by increasing the number and function of proinflammatory cells (B-2 cells, M1-polarized macrophages, CD8+ T cells, and IFN-Υ+ Th1 cells) and inducing, a prototypic T helper 1 inflammatory response, while downregulating anti-inflammatory cells (regulatory T cells and Natural killer T cells)27. Here, IFNA1 is linked to obesity due to melanocortin 4 receptor deficiency.