Finally, as CKD and aging share several similarities in regards to cardiovascular alterations15–17, including increased prevalence of LVH18, and serum FGF23 levels are also elevated in the non-CKD elderly population8, 19, 20, we determine if FGFR4 is required for aging-related LVH in mice. This evidence concerns the gene FGFR4 and chronic kidney disease.