According to the COSMIC database (http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MAPK1, accessed on August 16, 2016), somatic mutations (>74% missense) in MAPK1 have been reported in 89 unique samples, most frequently squamous cell carcinoma and more rarely in melanoma and lymphoid neoplasms, but none in JXG or any other histiocytic disorder. This evidence concerns the gene MAPK1 and melanoma.