Figure 5 shows how the effect estimates on Lp(a) relate to the ORs for CAD risk. Seven SNPs were even significantly associated with CAD on a genome-wide scale (P < 5 × 10−8). The highest effect was for rs186696265, which showed an OR of 1.73 (P = 3.35 × 10−30) with CAD risk for each copy of the minor allele (supplemental Table S13). This evidence concerns the gene LPA and coronary artery disorder.