Of relevance is the recent demonstration that the interaction of ITGβ4 and epidermal growth factor receptor (EGFR) is associated with poor prognosis in cancer patients since epidermal growth factor (EGF)-dependent signals stimulate ITGβ4-mediated migration of metastatic cells (Mainiero et al., 1996; Wang et al., 2014a). This evidence concerns the gene EGFR and cancer.