SLC5A2 and Hyperglycemia: SGLT2 inhibitors are specifically aimed to block the reabsorption of filtered glucose in the proximal renal tubule, and resulting in increased UGE and decreased glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG), especially when hyperglycaemia is present, in the meantime, they are protecting kidney [10, 11].