Moreover, controlling blood glucose with AHAs also attenuated the renal expression of mRNA for CYP11B2. These results indicated that spironolactone exerted renoprotective effects and inhibited local angiotensin-converting enzyme expression and the hyperglycemia-induced overexpression of CYP11B2 in the kidney [66]. Here, CYP11B2 is linked to Hyperglycemia.