It had been reported that GLP1-RAs could inhibit the potent inflammatory mediator NF-κB and decrease monocyte chemoattractant protein-1, intracellular cell adhesion molecule-1 and vascular cell adhesion molecule-1, which had been associated with abnormalities in vascular function and progression of DKD [59, 60]. This evidence concerns the gene GLP1R and diabetic kidney disease.