VIM and neoplasm: As seen in Yamato-SS xenograft models, not only spindle cells but also epithelial tumour cells were observed in SYO-1 xenograft tumours after TAS-115 administration (Additional file 6: Figure S6B), which was confirmed by immunohistochemical staining of anti-vimentin and anti-cytokeratin (AE1/AE3) antibodies (Additional file 9: Figure S8 and Additional file 8: Supplementary methods).