PDGFRA and soft tissue sarcoma: In October 2016, olaratumab, a monoclonal antibody of PDGFRα, received FDA approval for clinical use in combination with doxorubicin for unresectable and metastatic soft tissue sarcomas based upon the clinical data that olaratumab plus doxorubicin showed gains in median progression free and overall survival as compared to doxorubicin alone [51].