Consistent with this idea, 2 studies show that modulation of translation velocity is a robust strategy to correct folding errors in CF mutants [62, 63]: First, a global decrease of translation kinetics by varying codon choice [62] and second, knockdown of a ribosomal protein greatly increases the folding efficiency of ΔF508-CFTR [63]. This evidence concerns the gene CFTR and cystic fibrosis.