Meanwhile, another predictive factor for NAFLD, uric acid, was reportedly responsible for lipid metabolism impairment, including mitochondrial oxidative stress [56], sterol regulatory element-binding protein 1 (SREBP-1) activation induced by endoplasmic reticulum (ER) stress [57], and NLRP3 inflammasome involvement[58]. Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.