CDKN1B and T-cell non-Hodgkin lymphoma: Previously, the miR-M31-derived mature miRNA miR-M31-3p has been shown to share a conserved seed sequence with miR-221 [33], which targets and suppresses a key cell cycle inhibitory regulator p27Kip1 protein, together with miR-222, in the induction and progression of T-cell lymphomas [34].